San Francisco 49ers Fall 2021 Regular Season Game Schedule
| Date | Result | Opponent | Location | Status |
|---|---|---|---|---|
| Fri Aug 20 |
L
|
@
Saints
|
|
|
| Fri Aug 27 |
L
|
@
Rams
|
|
|
| Fri Sep 10 |
L
|
|
||
| Fri Sep 17 |
L
|
|
||
| Fri Sep 24 |
L
|
@
Arkansas
|
|
|
| Fri Oct 1 |
L
|
|
||
| Fri Oct 29 |
W
|
|
||
| Fri Oct 29 |
W
|
|